Searchable abstracts of presentations at key conferences in endocrinology

ea0094p204 | Metabolism, Obesity and Diabetes | SFEBES2023

Investigating the role of CaSR in mediating effect on glucose tolerance via α-cell and β-cell signalling

Chung Pei-En , Zhang Jiabai , Norton Mariana , Meyer Leah , Dunsterville Cecilia , Liu Jieruo , Gribble Fiona , Reimann Frank , Chang Wehan , Murphy Kevin

High protein diets are hypothesised to improve glucose tolerance by modulating the secretion of gastroenteropancreatic hormones via amino-acid sensing. Glucagon, traditionally associated with hyperglycaemia, has beneficial effects on glucose homeostasis, potentially due to its role as an insulin secretagogue via intra-islet signalling and as a regulator of pulsatile insulin secretion. The calcium sensing receptor (CaSR), known for its role in calcium homeostasis, also function...